Literature summary for 2.2.1.5 extracted from

Zaror-Behrens, G.; Mavrides, C.
Demonstration of 2-oxoglutarate:glyoxylate carboligase activity in Tetrahymena pyriformis (1973), Can. J. Biochem., 51, 1505-1508.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	-	Tetrahymena pyriformis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Tetrahymena pyriformis	5739	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Tetrahymena pyriformis
Mn2+	substitutes for Mg2+	Tetrahymena pyriformis

Organism

Organism	UniProt	Comment	Textmining
Tetrahymena pyriformis	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Tetrahymena pyriformis
0.128	-	maximum, cell-cycle-dependent	Tetrahymena pyriformis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + glyoxylate	-	Tetrahymena pyriformis	2-hydroxy-3-oxohexandioate + CO2	i. e. 2-hydroxy-3-oxoadipic acid	?
2-oxoglutarate + glyoxylate	-	Tetrahymena pyriformis	2-hydroxy-3-oxohexandioate + CO2	further spontaneous decarboxylation in the presence of acid	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	enzyme assay at	Tetrahymena pyriformis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	enzyme assay at	Tetrahymena pyriformis

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Tetrahymena pyriformis

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Release 2023.1 (January 2023)