Cloned (Comment) | Organism |
---|---|
gene AGAT, recombinant expression in HEK-293 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + glycine | Mus musculus | - |
L-ornithine + guanidinoacetate | - |
? | |
L-arginine + glycine | Mus musculus C57BL6 | - |
L-ornithine + guanidinoacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50440 | gene AGAT | - |
Mus musculus | Q9D964 | - |
- |
Mus musculus C57BL6 | Q9D964 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + glycine | - |
Mus musculus | L-ornithine + guanidinoacetate | - |
? | |
L-arginine + glycine | - |
Mus musculus C57BL6 | L-ornithine + guanidinoacetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGAT | - |
Homo sapiens |
L-arginine:glycine amidinotransferase | - |
Homo sapiens |
L-arginine:glycine amidinotransferase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | a guanidinoacetate N-methyltransferase deletion (GAMT-/-) causes gene AGAT upregulation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | AGAT deficiency (and consequently homoarginine and creatine deficiency) is associated with larger infarct volumes and worse neurological deficits compared with wild-type littermates. Homoarginine is absent in enzyme knockout AGAT-/- mice and increased in guanidinoacetate N-methyltransferase knockout mice, GAMT-/-. Cerebral damage and neurological deficits in experimental stroke are increased in AGAT-/- mice and attenuated by homoarginine supplementation, whereas infarct size in GAMT-/- mice is decreased compared with controls | Mus musculus |
metabolism | plasma homoarginine as strongly associated with single nucleotide polymorphisms in the L-arginine:glycine amidinotransferase (AGAT) gene, and increased AGAT expression in a cell model is associated with increased homoarginine, link between plasma homoarginine and outcome after experimental ischemic stroke. Allele-specific homoarginine plasma levels across the L-arginine:glycine amidinotransferase (AGAT) genotypes, overview | Homo sapiens |
metabolism | plasma homoarginine as strongly associated with single nucleotide polymorphisms in the L-arginine:glycine amidinotransferase (AGAT) gene, and increased AGAT expression in a cell model is associated with increased homoarginine, link between plasma homoarginine and outcome after experimental ischemic stroke. Allele-specific homoarginine plasma levels across the L-arginine:glycine amidinotransferase (AGAT) genotypes, overview | Mus musculus |