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Literature summary for 2.1.4.1 extracted from

  • Watanabe, Y.; Van Pilsum, J.F.; Yokoi, I.; Mori, A.
    Synthesis of neuroactive guanidino compounds by rat kidney L-arginine:glycine amidinotransferase (1994), Life Sci., 55, 351-358.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
glycine alpha-and beta-transamidinase Rattus norvegicus
14
-
arginine
-
Rattus norvegicus
14.3
-
arginine
-
Rattus norvegicus
23
-
lysine alpha-transamidinase Rattus norvegicus
23.5
-
lysine beta-transamidinase Rattus norvegicus
23.5
-
5-Aminovaleric acid beta-transamidinase Rattus norvegicus
23.9
-
5-Aminovaleric acid alpha-transamidinase Rattus norvegicus
24.9
-
4-aminobutyric acid beta-transamidinase Rattus norvegicus
27.2
-
4-aminobutyric acid alpha-transamidinase Rattus norvegicus
57.4
-
3-aminopropionic acid alpha-transamidinase Rattus norvegicus
57.5
-
3-aminopropionic acid beta-transamidinase Rattus norvegicus
163
-
ethanolamine
-
Rattus norvegicus
171
-
ethanolamine beta-transamidinase Rattus norvegicus
174
-
ethanolamine alpha-transamidinase Rattus norvegicus
392
-
taurine alpha-transamidinase Rattus norvegicus
450
-
ethanolamine beta-transamidinase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + glycine Mus musculus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Homo sapiens
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Rattus norvegicus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Oryctolagus cuniculus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Felis domestica
-
L-ornithine + guanidinoacetate
-
r

Organism

Organism UniProt Comment Textmining
Felis domestica
-
cat
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
-
-
Rattus norvegicus
-
rat
-
Rattus norvegicus Sprague-Dawley
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 fractions of enzyme, designated alpha- and beta transamidase individually purified Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Oryctolagus cuniculus
-
brain
-
Felis domestica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arginine + 3-aminopropionic acid
-
Homo sapiens 3-guanidinopropionic acid + ornithine
-
?
arginine + 3-aminopropionic acid
-
Rattus norvegicus 3-guanidinopropionic acid + ornithine
-
?
arginine + 4-aminobutyric acid
-
Homo sapiens 4-guanidinobutyric acid + ornithine
-
?
arginine + 4-aminobutyric acid
-
Rattus norvegicus 4-guanidinobutyric acid + ornithine
-
?
arginine + 4-aminobutyric acid
-
Oryctolagus cuniculus 4-guanidinobutyric acid + ornithine
-
?
arginine + 5-aminovaleric acid
-
Rattus norvegicus 5-guanidinovaleric acid + ornithine
-
?
arginine + ethanolamine
-
Homo sapiens 2-guanidinoethanol + ornithine
-
?
arginine + ethanolamine
-
Rattus norvegicus 2-guanidinoethanol + ornithine
-
?
arginine + ethanolamine
-
Oryctolagus cuniculus 2-guanidinoethanol + ornithine
-
?
arginine + ethanolamine
-
Rattus norvegicus Sprague-Dawley 2-guanidinoethanol + ornithine
-
?
arginine + lysine
-
Rattus norvegicus homoarginine + ornithine
-
?
arginine + taurine
-
Mus musculus 2-guanidinoethanesulfonic acid + ornithine
-
?
arginine + taurine
-
Rattus norvegicus 2-guanidinoethanesulfonic acid + ornithine
-
?
canavanine + glycine
-
Homo sapiens guanidinoacetate + canaline
-
r
canavanine + glycine
-
Rattus norvegicus guanidinoacetate + canaline
-
r
canavanine + glycine
-
Rattus norvegicus Sprague-Dawley guanidinoacetate + canaline
-
r
canavanine + ornithine
-
Mus musculus arginine + canaline
-
r
canavanine + ornithine
-
Homo sapiens arginine + canaline
-
r
canavanine + ornithine
-
Rattus norvegicus arginine + canaline
-
r
canavanine + ornithine
-
Oryctolagus cuniculus arginine + canaline
-
r
canavanine + ornithine
-
Felis domestica arginine + canaline
-
r
canavanine + ornithine
-
Rattus norvegicus Sprague-Dawley arginine + canaline
-
r
homoarginine + glycine
-
Homo sapiens homoornithine + guanidinoacetate
-
r
homoarginine + glycine
-
Rattus norvegicus homoornithine + guanidinoacetate
-
r
homoarginine + glycine
-
Rattus norvegicus Sprague-Dawley homoornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Mus musculus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Homo sapiens L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Rattus norvegicus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Oryctolagus cuniculus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Felis domestica L-ornithine + guanidinoacetate
-
r
additional information L-glutamic acid, L-aspartic acid and histidine are no substrates Rattus norvegicus ?
-
?
additional information L-glutamic acid, L-aspartic acid and histidine are no substrates Rattus norvegicus Sprague-Dawley ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
synthesis of guanidinoacetic acid Rattus norvegicus
8.3
-
synthesis of 4-guanidinobutyric acid Rattus norvegicus
8.4
-
synthesis of homoarginine Rattus norvegicus
8.6
-
synthesis of 5-guanidinovaleric acid Rattus norvegicus
9.2
-
synthesis of 3-guanidinopropionic acid, 2-guanidinoethanol and 2-guanidinoethanesulfonic acid Rattus norvegicus