Literature summary for 2.1.4.1 extracted from

Walker, J.B.
Studies on the mechanism of action of kidney transamidinase (1957), J. Biol. Chem., 224, 57-66.

Activating Compound

Activating Compound	Comment	Organism
cysteine	relative activity 103%	Rattus norvegicus
cysteine	relative activity 103%	Sus scrofa
thiolhistidine	relative activity 102%	Rattus norvegicus
thiolhistidine	relative activity 102%	Sus scrofa
Thiourea	relative activity 104%	Rattus norvegicus
Thiourea	relative activity 104%	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism
2-thio-6-aminouracil	plus ferricyanide, strong inhibition	Rattus norvegicus
2-thio-6-aminouracil	plus ferricyanide, strong inhibition	Sus scrofa
2-thio-6-oxopurine	plus ferricyanide, strong inhibition	Rattus norvegicus
2-thio-6-oxopurine	plus ferricyanide, strong inhibition	Sus scrofa
2-Thiouracil	plus ferricyanide, strong inhibition	Rattus norvegicus
2-Thiouracil	plus ferricyanide, strong inhibition	Sus scrofa
2-thiouracil-5-carboxylic acid	plus ferricyanide, strong inhibition	Rattus norvegicus
2-thiouracil-5-carboxylic acid	plus ferricyanide, strong inhibition	Sus scrofa
Cu2+	-	Rattus norvegicus
Cu2+	-	Sus scrofa
dithiobiuret	plus ferricyanide, strong inhibition	Rattus norvegicus
dithiobiuret	plus ferricyanide, strong inhibition	Sus scrofa
ornithine	above 1 mg per ml guanidinoacetate-ornithine transamidination is inhibited	Rattus norvegicus
ornithine	above 1 mg per ml guanidinoacetate-ornithine transamidination is inhibited	Sus scrofa
p-chloromercuribenzoate	-	Rattus norvegicus
p-chloromercuribenzoate	-	Sus scrofa
thiolhistidine	plus ferricyanide, strong inhibition	Rattus norvegicus
thiolhistidine	plus ferricyanide, strong inhibition	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
L-arginine + glycine	Rattus norvegicus	-	L-ornithine + guanidinoacetate	-	r
L-arginine + glycine	Sus scrofa	-	L-ornithine + guanidinoacetate	-	r
L-ornithine + guanidinoacetate	Sus scrofa	-	L-arginine + glycine	-	r

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	rat	-
Sus scrofa	-	pig, porcine, hog	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
arginine + hydroxylamine	-	Rattus norvegicus	ornithine + hydroxyguanidine	-	?
arginine + hydroxylamine	-	Sus scrofa	ornithine + hydroxyguanidine	-	?
arginine + ornithine	-	Rattus norvegicus	ornithine + arginine	-	?
arginine + ornithine	-	Sus scrofa	ornithine + arginine	-	?
canavanine + canaline	-	Rattus norvegicus	canaline + canavanine	-	?
canavanine + canaline	-	Sus scrofa	canaline + canavanine	-	?
canavanine + glycine	-	Rattus norvegicus	guanidinoacetate + canaline	-	r
canavanine + glycine	-	Sus scrofa	guanidinoacetate + canaline	-	r
canavanine + hydroxylamine	-	Rattus norvegicus	canaline + hydroxyguanidine	-	?
canavanine + hydroxylamine	-	Sus scrofa	canaline + hydroxyguanidine	-	?
canavanine + ornithine	-	Rattus norvegicus	arginine + canaline	-	r
canavanine + ornithine	-	Sus scrofa	arginine + canaline	-	r
glycine + guanidinoacetate	-	Rattus norvegicus	guanidinoacetate + glycine	-	r
glycine + guanidinoacetate	-	Sus scrofa	guanidinoacetate + glycine	-	r
guanidinoacetate + canaline	-	Rattus norvegicus	glycine + canavanine	-	?
guanidinoacetate + canaline	-	Sus scrofa	glycine + canavanine	-	?
guanidinoacetate + hydroxylamine	-	Rattus norvegicus	hydroxyguanidine + glycine	-	?
guanidinoacetate + hydroxylamine	-	Sus scrofa	hydroxyguanidine + glycine	-	?
guanidinoacetate + ornithine	-	Rattus norvegicus	glycine + arginine	-	?
guanidinoacetate + ornithine	-	Sus scrofa	glycine + arginine	-	?
L-arginine + glycine	-	Rattus norvegicus	L-ornithine + guanidinoacetate	-	r
L-arginine + glycine	-	Sus scrofa	L-ornithine + guanidinoacetate	-	r
L-ornithine + guanidinoacetate	-	Sus scrofa	L-arginine + glycine	-	r