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Literature summary for 2.1.2.1 extracted from
- Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase (1998), Protein Expr. Purif., 13, 177-183.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Oryctolagus cuniculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
tetrahydrofolate | recombinant enzyme | Oryctolagus cuniculus |  |
| 0.15 | 0.9 | L-serine | recombinant enzyme | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + tetrahydrofolate | Oryctolagus cuniculus | enzyme is a component of thymidylate cycle | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Oryctolagus cuniculus | catalyzes interconversion of serine and glycine | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + tetrahydrofolate | - |
Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
r | |
| L-serine + tetrahydrofolate | enzyme is a component of thymidylate cycle | Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | catalyzes interconversion of serine and glycine | Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10.5 | - |
L-serine | - |
Oryctolagus cuniculus | |
| 14.2 | - |
L-serine | recombinant enzyme | Oryctolagus cuniculus | |
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