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Literature summary for 2.1.1.77 extracted from

  • Biterge, B.; Richter, F.; Mittler, G.; Schneider, R.
    Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis (2014), Sci. Rep., 4, 6674.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + histone H4 D-aspartate Homo sapiens
-
S-adenosyl-L-homocysteine + histone H4 D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-Select nickel affinity gel column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H4 D-aspartate
-
Homo sapiens S-adenosyl-L-homocysteine + histone H4 D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Synonyms

Synonyms Comment Organism
PCMT1
-
Homo sapiens
protein L-isoaspartate O-methyltransferase
-
Homo sapiens