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Literature summary for 2.1.1.77 extracted from

  • Banerjee, S.; Dutta, T.; Lahiri, S.; Sengupta, S.; Gangopadhyay, A.; Kumar Karri, S.; Chakraborty, S.; Bhattacharya, D.; Ghosh, A.
    Enzymatic attributes of an l-isoaspartyl methyltransferase from (2015), Biochem. Biophys. Rep., 4, 59-75.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
Cyberlindnera jadinii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
S-adenosyl-L-methionine at pH 7.0 and 30°C Cyberlindnera jadinii
0.03336
-
delta sleep inducing peptide L-isoaspartate at pH 7.0 and 30°C Cyberlindnera jadinii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
x * 25000, SDS-PAGE Cyberlindnera jadinii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein D-aspartate Cyberlindnera jadinii
-
S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Cyberlindnera jadinii
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, BioSuite SEC gel filtration, and ProteinPak 125 gel filtration Cyberlindnera jadinii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.4014
-
crude enzyme, at pH 7.0 and 30°C Cyberlindnera jadinii
17.01
-
after 43.41fold purification, at pH 7.0 and 30°C Cyberlindnera jadinii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + bovine serum albumin L-isoaspartate enzyme activity is lowest against bovine serum albumin but it doubles when the bovine serum albumin is aged upon incubation in in vitro aging buffer Cyberlindnera jadinii S-adenosyl-L-homocysteine + bovine serum albumin L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + delta sleep inducing peptide L-isoaspartate highest activity Cyberlindnera jadinii S-adenosyl-L-homocysteine + delta sleep inducing peptide L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + gamma-globulin L-isoaspartate
-
Cyberlindnera jadinii S-adenosyl-L-homocysteine + gamma-globulin L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + ovalbumin L-isoaspartate
-
Cyberlindnera jadinii S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Cyberlindnera jadinii S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Cyberlindnera jadinii S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Cyberlindnera jadinii

Synonyms

Synonyms Comment Organism
L-isoaspartyl methyltransferase
-
Cyberlindnera jadinii
PCMT
-
Cyberlindnera jadinii
protein-L-isoaspartate (D-aspartate) O-methyltransferase
-
Cyberlindnera jadinii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Cyberlindnera jadinii

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30 40 the enzyme is most stable between 30 and 40°C Cyberlindnera jadinii

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
203.9
-
S-adenosyl-L-methionine at pH 7.0 and 30°C Cyberlindnera jadinii
233.3
-
delta sleep inducing peptide L-isoaspartate at pH 7.0 and 30°C Cyberlindnera jadinii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Cyberlindnera jadinii

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5 7.5 the enzyme is most stable between pH 6.5 and 7.5 Cyberlindnera jadinii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.5
-
S-adenosyl-L-homocysteine at pH 7.0 and 30°C Cyberlindnera jadinii