Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein p53 | the enzyme mediates methylation of protein p53 at isoaspartate residues 29 and 30 | Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Homo sapiens |
protein L-isoaspartyl methyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion upregulates the proapoptotic and checkpoint activation functions of p53 | Homo sapiens |
physiological function | the enzyme negatively regulates the tumour suppressor protein p53 by reducing p53 protein levels, thereby suppressing the p53-mediated transcription of target genes. The enzyme destabilizes p53 by enhancing the p53-HDM2 interaction | Homo sapiens |