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Literature summary for 2.1.1.77 extracted from

  • Cimmino, A.; Capasso, R.; Muller, F.; Sambri, I.; Masella, L.; Raimo, M.; De Bonis, M.L.; DAngelo, S.; Zappia, V.; Galletti, P.; Ingrosso, D.
    Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation (2008), PLoS ONE, 3, e3258.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.77

Cloned(Commentary)

Cloned (Comment) Organism
expressed in porcine aortic endothelial cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D83F negative dominant mutant Homo sapiens
D83V negative dominant mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens PCMT catalyzes methyl esterification of the free alpha-carboxyl group at the isoaspartyl site, thus initiating the repair of the abnormal protein through the conversion of the isopeptide bond into a normal alpha-peptide bond S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + actin L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + actin L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + Bcl-xL L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + Bcl-xL L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + Hsp70 L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + Hsp70 L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + Hsp90 L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + Hsp90 L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + ovalbumin L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + protein L-isoaspartate PCMT catalyzes methyl esterification of the free alpha-carboxyl group at the isoaspartyl site, thus initiating the repair of the abnormal protein through the conversion of the isopeptide bond into a normal alpha-peptide bond Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
isoaspartyl protein carboxyl-O-methyltransferase
-
 Homo sapiens
PCMT
-
 Homo sapiens
protein isoaspartate methyltransferase
-
 Homo sapiens
protein isoaspartyl carboxyl O-methyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PCMT maintains the functional stability of antiapoptotic proteins, PCMT when overexpressed in endothelial cells is able to prevent apoptosis induced by H2O2 treatment Homo sapiens