Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.77 extracted from

  • Gomez, T.A.; Banfield, K.L.; Clarke, S.G.
    The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response (2008), Mech. Ageing Dev., 129, 752-758.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.77

Cloned(Commentary)

Cloned (Comment) Organism
-
 Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
actomyosin
-
 Caenorhabditis elegans 42641
-
cytoplasm
-
 Caenorhabditis elegans 5737
-
nucleus
-
 Caenorhabditis elegans 5634
-
perikaryon
-
 Caenorhabditis elegans 43204
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
body wall
-
 Caenorhabditis elegans
-
distal tip
-
 Caenorhabditis elegans
-
enteric muscle
-
 Caenorhabditis elegans
-
gonad
-
 Caenorhabditis elegans
-
hypodermis
-
 Caenorhabditis elegans
-
neural cord
-
 Caenorhabditis elegans
-
neuron
-
 Caenorhabditis elegans
-
neuron head region, lateral interneurons and tail region Caenorhabditis elegans
-
pharyngeal muscle
-
 Caenorhabditis elegans
-
pharynx
-
 Caenorhabditis elegans
-
reproductive tissue
-
 Caenorhabditis elegans
-
spermathecum
-
 Caenorhabditis elegans
-
vulva
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
PCM-1
-
 Caenorhabditis elegans
protein L-isoaspartyl-O-methyltransferase
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Caenorhabditis elegans

Expression

Organism Comment Expression
Caenorhabditis elegans pcm-1 dauer and dauer-like larvae display an average of 46% decrease in lifespan in comparison to N2 dauer and dauer-like larvae down
Caenorhabditis elegans upon heat shock and dauer formation-inducing conditions, there is additional pcm-1 expression in body wall muscle nuclei and actomyosin filaments and in hypodermal cells up

General Information

General Information Comment Organism
physiological function worms lacking the pcm-1 gene exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation stress, while overexpression leads to increased adult longevity Caenorhabditis elegans