Literature summary for 2.1.1.63 extracted from

Jena, N.R.; Shukla, P.K.; Jena, H.S.; Mishra, P.C.; Suhai, S.
O6-methylguanine repair by O6-alkylguanine-DNA alkyltransferase (2009), J. Phys. Chem. B, 113, 16285-16290.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?
additional information	in the catalytic demethylation of DNA containing 6-O-methylguanine, roles of six amino acids, i.e., Cys145, His146, Glu172, Tyr114, Lys165, and Ser159 are involved. At the first step, Cys145 in the Cys145-water-His146-Glu172 tetrad is converted to cysteine thiolate anion while at the second step, abstraction of the Tyr114 proton by the N3 site of DNA containing 6-O-methylguanine occurs in a barrierless manner. In the third step, abstraction of Lys165 proton by deprotonated Tyr114 and transfer of the methyl group of DNA containing 6-O-methylguanine to the thiolate group of Cys145 anion occur simultaneously.	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
AGT	-	Homo sapiens
MGMT	-	Homo sapiens
O6-alkylguanine-DNA alkyltransferase	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)