Literature summary for 2.1.1.63 extracted from

Roberts, A.; Pelton, J.G.; Wemmer, D.E.
Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase (2006), Magn. Reson. Chem., 44, S71-S82.

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Cloned(Commentary)

Cloned (Comment)	Organism
transformed into Escherichia coli BL21(DE3)	Methanocaldococcus jannaschii

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
on NaCl gradient	Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Methanocaldococcus jannaschii	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Subunits

Subunits	Comment	Organism
More	structure analysis by multinuclear multidimensional NMR spectroscopy, a two-domain protein with an alpha/beta fold, N-terminal domain consists of a three-stranded antiparallel beta sheet, N-terminus is somewhat less well defined than the C-terminus, structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain, whereas the C-terminal domain is more highly conserved in both sequence and structure	Methanocaldococcus jannaschii

Synonyms

Synonyms	Comment	Organism
MGMT	-	Methanocaldococcus jannaschii
MJ1529	-	Methanocaldococcus jannaschii
O6-methylguanine-DNA methyltransferase	-	Methanocaldococcus jannaschii

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Release 2023.1 (January 2023)