Literature summary for 2.1.1.63 extracted from

Bacolod, M.D.; Johnson, S.P.; Pegg, A.E.; Dolan, M.E.; Moschel, R.C.; Bullock, N.S.; Fang, Q.; Colvin, O.M.; Modrich, P.; Bigner, D.D.; Friedman, H.S.
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations (2004), Mol. Cancer Ther., 3, 1127-1135.

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Application

Application	Comment	Organism
medicine	clonal selection of AGT mutants during trteatment with O6-benzylguanine plus an alkylator may produce resistance to this intervention in clinical settings	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G156C	mutant form expressed by the medulloblastoma cell line D283 MED, mutant enzyme is not easily inhibited by O6-benzylguanine	Homo sapiens
K165T	mutant form expressed by the medulloblastoma cell line D341 MED, mutant enzyme is not easily inhibited by O6-benzylguanine	Homo sapiens
Y114F	mutant form expressed by the medulloblastoma cell line Daoy, mutant enzyme is not easily inhibited by O6-benzylguanine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
medulloblastoma cell	D283 MED, D341 MED and Daoy	Homo sapiens	-

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Release 2023.1 (January 2023)