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Literature summary for 2.1.1.63 extracted from

  • Guengerich, F.P.; Fang, Q.; Liu, L.; Hachey, D.L.; Pegg, A.E.
    O6-Alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145 (2003), Biochemistry, 42, 10965-10970.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ Cys145 in hAGT exists as a reactive thiolate anion at neutral pH. The low pKa of Cys145 is dependent upon the bound Zn2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
hAGT
-
Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
Homo sapiens