Inhibitors | Comment | Organism | Structure |
---|---|---|---|
salvianolic acid B | weak inhibitor. In vivo, a single intravenous dose of salvianolic acid B decreases the plasma concentration of 3-O-methyldopa, with no obvious effect on the pharmacokinetics of L-dopa | Rattus norvegicus | |
tolcapone | strongly inhibits the formation of 3-methylsalvianolic acid B in vitro and in vivo, without any change in its plasma concentration. Tolcapone significantly increases the cumulative bile excretion of salvianolic acid from 3% to 40% in the rat | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0113 | - |
salvianolic acid B | lung tissue preparation, 37°C, pH not specified in the publication | Rattus norvegicus | |
0.0162 | - |
salvianolic acid B | intestine tissue preparation, 37°C, pH not specified in the publication | Rattus norvegicus | |
0.07 | - |
salvianolic acid B | kidney tissue preparation, 37°C, pH not specified in the publication | Rattus norvegicus | |
0.0797 | - |
salvianolic acid B | liver tissue preparation, 37°C, pH not specified in the publication | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dopa + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + 3-O-methyl-L-dopa | - |
? | |
salvianolic acid B + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
salvianolic acid B | 37°C, pH not specified in the publication | Rattus norvegicus |