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Literature summary for 2.1.1.6 extracted from

  • Suriguga, M.; Li, X.F.; Li, Y.; Yu, C.H.; Li, Y.R.; Yi, Z.C.
    The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells (2013), Toxicol. Appl. Pharmacol., 273, 635-643.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
K-562 cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function exposure to catechol enhances hemin-induced hemoglobin accumulation and induces mRNA expression of erythroid-specific genes in K-562 cells. Treatment with catechol causes a time- and concentration-dependent increase in guaiacol concentration in the medium of cultured K-562 cells. Knock down of COMT expression significantly reduces the production of guaiacol, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increases. Knockdown of COMT expression also eliminates catechol-enhanced erythroid differentiation of K-562 cells. The pretreatment with S-adenosyl-L-methionine or S-adenosyl-L-homocysteine induces a significant increase in hemin-induced hemoglobin synthesis in K-562 cells and the mRNA expression of erythroid specific genes Homo sapiens