Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one | - |
Homo sapiens | |
1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one | - |
Rattus norvegicus | |
1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | - |
Rattus norvegicus | |
5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | - |
Rattus norvegicus | |
tolcapone | inhibitor of isoform MB-COMT, substrate of isoform S-COMT | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | isoform MB-COMT | Homo sapiens | 16020 | - |
membrane | isoform MB-COMT | Rattus norvegicus | 16020 | - |
soluble | isoform S-COMT | Homo sapiens | - |
- |
soluble | isoform S-COMT | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | membrane-bound isoform MB-COMT is predominant | Homo sapiens | - |
brain | membrane-bound isoform MB-COMT is predominant | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tolcapone + S-adenosyl-L-methionine | inhibitor of isoform MB-COMT, substrate of isoform S-COMT | Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
tolcapone + S-adenosyl-L-methionine | substrate of both isoform S-COMT and isoform MB-COMT | Rattus norvegicus | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MB-COMT | - |
Homo sapiens |
MB-COMT | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000067 | - |
isoform MB-COMT, pH 7.4, 37°C | Homo sapiens | tolcapone | |
0.000013 | - |
isoform MB-COMT, pH 7.4, 37°C | Rattus norvegicus | 5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | |
0.0000265 | - |
isoform MB-COMT, pH 7.4, 37°C | Rattus norvegicus | 1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one | |
0.0000274 | - |
isoform MB-COMT, pH 7.4, 37°C | Rattus norvegicus | 1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.000039 | - |
isoform MB-COMT, pH 7.4, 37°C | Homo sapiens | 1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.0000449 | - |
isoform MB-COMT, pH 7.4, 37°C | Homo sapiens | 1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one | |
0.000063 | - |
isoform MB-COMT, pH 7.4, 37°C | Homo sapiens | 5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | |
0.000175 | - |
isoform S-COMT, pH 7.4, 37°C | Homo sapiens | 5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | |
0.000226 | - |
isoform S-COMT, pH 7.4, 37°C | Homo sapiens | 1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.000237 | - |
isoform S-COMT, pH 7.4, 37°C | Rattus norvegicus | 1-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.000565 | - |
isoform S-COMT, pH 7.4, 37°C | Rattus norvegicus | 5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one | |
0.000857 | - |
isoform S-COMT, pH 7.4, 37°C | Homo sapiens | 1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one | |
0.000881 | - |
isoform S-COMT, pH 7.4, 37°C | Rattus norvegicus | 1-[1-(2-chlorobenzyl)-1H-benzimidazol-4-yl]-3-hydroxypyridin-4(1H)-one |