Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
L16P | missense mutation | Homo sapiens |
additional information | the add mutation substantially diminishes COMT1 methyltransferase activity toward norepinephrine | Mus musculus |
Y71X | the mutation is predicted to truncate the protein before the catalytic domain likely affecting methyltransferase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cochlea | isoform COMT2 | Mus musculus | - |
hair cell | COMT2 is highly expressed in sensory hair cells of the inner ear | Mus musculus | - |
hair cell | COMT2 is highly expressed in sensory hair cells of the inner ear | Homo sapiens | - |
inner ear vestibulum | isoform COMT2 | Mus musculus | - |
additional information | isoform COMT2 is not expressed in the central nervous system | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
norepinephrine + S-adenosyl-L-methionine | - |
Mus musculus | S-adenosyl-L-homocysteine + normetanephrine | - |
? | |
norepinephrine + S-adenosyl-L-methionine | - |
Homo sapiens | S-adenosyl-L-homocysteine + normetanephrine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COMT1 | isoform | Mus musculus |
COMT1 | isoform | Homo sapiens |
COMT2 | isoform | Mus musculus |
COMT2 | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | catechol-O-methyltransferase COMT2 is essential for auditory function | Mus musculus |
physiological function | catechol-O-methyltransferase COMT2 is essential for auditory function | Homo sapiens |