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Literature summary for 2.1.1.6 extracted from

  • Meyers, B.; DAgostino, A.; Walker, J.; Kritzer, M.
    Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats (2010), Neuroscience, 165, 850-862.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
tropolone
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform COMT-s Rattus norvegicus 5829
-
membrane isoform COMT-mb Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neostriatum
-
 Rattus norvegicus
-
prefrontal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
catechol + S-adenosyl-L-methionine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
COMT
-
 Rattus norvegicus
COMT-mb catechol-O-methyltransferase, membrane-bound isoform Rattus norvegicus
COMT-s catechol-O-methyltransferase, soluble isoform Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus there are no effects of gonadectomy itself on COMT-s activity, there are significant effects of hormone replacement (supplementation with testosterone propionate or with estradiol for 28 days) but not gonadectomy on the soluble but not the membrane-bound isoform of catechol-O-methyltransferase in both striatum and brain cortex additional information