Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-dihydroxy-4-[2-(methylamino)butyl]benzene | uncompetitive inhibitor of the sCOMT isoform | Homo sapiens | |
3,4-dihydroxymethamphetamine | uncompetitive inhibitor of the sCOMT isoform | Homo sapiens | |
N-ethyl-3,4-dihydroxyamphetamine | uncompetitive inhibitor of the sCOMT isoform | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
(R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | |
0.02 | - |
(S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | |
0.03 | - |
(R)-3,4-dihydroxymethamphetamine | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | |
0.03 | - |
(S)-3,4-dihydroxymethamphetamine | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | |
0.07 | - |
(S)-N-ethyl-3,4-dihydroxyamphetamine | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | |
0.09 | - |
(R)-N-ethyl-3,4-dihydroxyamphetamine | isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | isoform mbCOMT | Homo sapiens | 16020 | - |
microsome | isoform mbCOMT | Homo sapiens | - |
- |
soluble | isoform sCOMT | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
(R)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
(R)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
(S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
(S)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
(S)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
3-hydroxytyramine + S-adenosyl-L-methionine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 3-methoxytyramine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Homo sapiens |
SCOMT | soluble isoform | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.1 | - |
isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | N-ethyl-3,4-dihydroxyamphetamine | |
0.2 | - |
isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | 3,4-dihydroxymethamphetamine | |
0.3 | - |
isoform sCOMT, in phosphate buffer (pH 7.4) | Homo sapiens | 1,2-dihydroxy-4-[2-(methylamino)butyl]benzene |