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Literature summary for 2.1.1.6 extracted from

  • Nackley, A.G.; Tan, K.S.; Fecho, K.; Flood, P.; Diatchenko, L.; Maixner, W.
    Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta 2- and beta 3-adrenergic receptors (2007), Pain, 128, 199-208.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine low COMT activity leads to increased pain sensitivity via a beta2/3-adrenergic mechanism. These findings are of considerable clinical importance, suggesting that pain conditions resulting from low COMT activity and/or elevated catecholamine levels can be treated with pharmacological agents that block both beta2- and beta3-adrenergic receptors Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
OR486 depressed COMT activity results in enhanced mechanical and thermal pain sensitivity Rattus norvegicus
Ro41-0960 depressed COMT activity results in enhanced mechanical and thermal pain sensitivity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Synonyms

Synonyms Comment Organism
COMT
-
 Rattus norvegicus