Application | Comment | Organism |
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medicine | catechol-O-methyltransferase activity and protein expression are increased in the substantia nigra after inflammation induced by lipopolysaccharides. These changes in glial and perivascular catechol-O-methyltransferase activity may have clinical relevance for Parkinsons disease drug treatment due to increased metabolism of levodopa in the brain | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
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brain | paranigral lipopolysaccharide infusion to rats results in intense microglial activation around the lesion area followed by a delayed injury in nigrostriatal pathway in 2 weeks. Simultaneously, catechol-O-methyltransferase activity in the substantia nigra is gradually increased up to 213%. Soluble COMT and membrane bound COMT proteins are increased by 255% and 86%, respectively. Increased catechol-O-methyltransferase immunoreactivity is located primarily into the activated microglial cells in the lesion area | Rattus norvegicus | - |
Synonyms | Comment | Organism |
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COMT | - |
Rattus norvegicus |