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Literature summary for 2.1.1.6 extracted from

  • Rutherford, K.; Le Trong, I.; Stenkamp, R.E.; Parson, W.W.
    Crystal structures of human 108V and 108M catechol O-methyltransferase (2008), J. Mol. Biol., 380, 120-130.
    View publication on PubMed
Search for more literature for 2.1.1.6

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor-diffusion method, crystal structures of the 108V and 108M variants of the soluble form of human COMT bound with S-adenosylmethionine and a substrate analog, 3,5-dinitrocatechol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin-3-O-gallate potent non-competitive inhibitor Homo sapiens
(-)-epigallocatechin-3-O-gallate potent non-competitive inhibitor Rattus norvegicus
(-)-epigallocatechin-3-O-gallate potent non-competitive inhibitor Sus scrofa
catechin
-
 Homo sapiens
catechin
-
 Rattus norvegicus
catechin
-
 Sus scrofa
epicatechin
-
 Homo sapiens
epicatechin
-
 Rattus norvegicus
epicatechin
-
 Sus scrofa
epigallocatechin
-
 Homo sapiens
epigallocatechin
-
 Rattus norvegicus
epigallocatechin
-
 Sus scrofa
fisetin
-
 Homo sapiens
fisetin
-
 Rattus norvegicus
fisetin
-
 Sus scrofa
quercetin
-
 Homo sapiens
quercetin
-
 Rattus norvegicus
quercetin
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21964
-
-
Rattus norvegicus P22734
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-epigallocatechin-3-O-gallate + S-adenosyl-L-methionine poor substrate for methylation Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2-hydroxyestradiol + S-adenosyl-L-methionine
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
2-hydroxyestradiol + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2-hydroxyestradiol + S-adenosyl-L-methionine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
4-hydroxyestradiol + S-adenosyl-L-methionine
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
4-hydroxyestradiol + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
4-hydroxyestradiol + S-adenosyl-L-methionine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
catechol-O-methyltransferase
-
 Sus scrofa
catechol-O-methyltransferase
-
 Homo sapiens
catechol-O-methyltransferase
-
 Rattus norvegicus
COMT
-
 Sus scrofa
COMT
-
 Homo sapiens
COMT
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00007
-
 O-methylation of 2-hydroxyestradiol Homo sapiens (-)-epigallocatechin-3-O-gallate
0.00054
-
 O-methylation of 4-hydroxyestradiol Homo sapiens (-)-epigallocatechin-3-O-gallate
0.0009
-
 O-methylation of 4-hydroxyestradiol Homo sapiens quercetin
0.0012
-
 O-methylation of 2-hydroxyestradiol Homo sapiens quercetin
0.0012
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus (-)-epigallocatechin-3-O-gallate
0.0012
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus (-)-epigallocatechin-3-O-gallate
0.0015
-
 O-methylation of 2-hydroxyestradiol Sus scrofa (-)-epigallocatechin-3-O-gallate
0.0017
-
 O-methylation of 4-hydroxyestradiol Sus scrofa (-)-epigallocatechin-3-O-gallate
0.0021
-
 O-methylation of 4-hydroxyestradiol Sus scrofa quercetin
0.0021
-
 O-methylation of 4-hydroxyestradiol Homo sapiens fisetin
0.0021
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus fisetin
0.0022
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus quercetin
0.0032
-
 O-methylation of 4-hydroxyestradiol Sus scrofa fisetin
0.0035
-
 O-methylation of 2-hydroxyestradiol Homo sapiens fisetin
0.0035
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus fisetin
0.0039
-
 O-methylation of 2-hydroxyestradiol Sus scrofa quercetin
0.0043
-
 O-methylation of 2-hydroxyestradiol Sus scrofa fisetin
0.0045
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus quercetin
0.006
-
 O-methylation of 4-hydroxyestradiol Homo sapiens epigallocatechin
0.0066
-
 O-methylation of 4-hydroxyestradiol Homo sapiens catechin
0.008
-
 O-methylation of 4-hydroxyestradiol Sus scrofa catechin
0.012
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus catechin
0.015
-
 O-methylation of 2-hydroxyestradiol Homo sapiens epigallocatechin
0.015
-
 O-methylation of 4-hydroxyestradiol Homo sapiens epicatechin
0.0153
-
 O-methylation of 2-hydroxyestradiol Homo sapiens catechin
0.016
-
 O-methylation of 2-hydroxyestradiol Sus scrofa catechin
0.019
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus catechin
0.019
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus epicatechin
0.02
-
 O-methylation of 4-hydroxyestradiol Rattus norvegicus epigallocatechin
0.022
-
 O-methylation of 4-hydroxyestradiol Sus scrofa epigallocatechin
0.039
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus epigallocatechin
0.04
-
 O-methylation of 2-hydroxyestradiol Rattus norvegicus epicatechin
0.048
-
 O-methylation of 2-hydroxyestradiol Sus scrofa epigallocatechin
0.0532
-
 O-methylation of 2-hydroxyestradiol Homo sapiens epicatechin
0.062
-
 O-methylation of 2-hydroxyestradiol Sus scrofa epicatechin
0.068
-
 O-methylation of 4-hydroxyestradiol Sus scrofa epicatechin