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Literature summary for 2.1.1.6 extracted from
- Oxidative inhibition of human soluble catechol-O-methyltransferase (2004), J. Biol. Chem., 279, 23710-23718.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C69S | mutation makes variant 108V and 108M more sensitive to oxidation | Homo sapiens |
| C95S | mutation increases the activity measured in absence of dithiothreitol in both the 108V and the 108M variant | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
variants 108M and 108V | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COMT | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
variants 108M and 108V differ in their thermal stability with COMT losing catalytic activity more rapidly | Homo sapiens |
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Release 2023.1 (January 2023)
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