KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0055 | - |
norepinephrine | corebral cortex, membrane-bound form | Rattus norvegicus | |
0.00587 | - |
norepinephrine | cerebellum, membrane-bound form | Rattus norvegicus | |
0.00697 | - |
S-adenosyl-L-methionine | soluble enzyme | Rattus norvegicus | |
0.00837 | - |
norepinephrine | brain stem, membrane-bound form | Rattus norvegicus | |
0.00912 | - |
norepinephrine | hippocampus, membrane-bound form | Rattus norvegicus | |
0.0105 | - |
norepinephrine | hypophysis, membrane-bound form | Rattus norvegicus | |
0.0113 | - |
S-adenosyl-L-methionine | membrane-bound enzyme | Rattus norvegicus | |
0.0114 | - |
norepinephrine | hypothalamus, membrane-bound form | Rattus norvegicus | |
0.304 | - |
norepinephrine | corebral cortex, soluble enzyme | Rattus norvegicus | |
0.305 | - |
norepinephrine | hippocampus, soluble enzyme | Rattus norvegicus | |
0.313 | - |
norepinephrine | cerebellum, soluble enzyme | Rattus norvegicus | |
0.39 | - |
norepinephrine | brain stem, soluble enzyme | Rattus norvegicus | |
0.443 | - |
norepinephrine | hypothalamus, soluble enzyme | Rattus norvegicus | |
0.465 | - |
norepinephrine | hypophysis, soluble enzyme | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound to.In all brain areas membrane-bound enzyme activity is lower than soluble enzyme activity | Rattus norvegicus | 16020 | - |
soluble | in all brain areas membrane-bound enzyme activity is lower than soluble enzyme activity | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | Km: 0.22 mM for soluble enzyme, 0.17 mM for membrane-bound enzyme | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | highest activity in hippocampus. In all brain areas membrane-bound enzyme activity is lower than soluble enzyme activity | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 3,4-dihydroxybenzoic acid | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + norepinephrine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
membrane-bound enzyme | Rattus norvegicus |
7.8 | - |
soluble enzyme | Rattus norvegicus |