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Literature summary for 2.1.1.6 extracted from

  • Yan, M.; Webster, L.T., Jr.; Blumer, J.L.
    Kinetic interactions of dopamine and dobutamine with human catechol-O-methyltransferase and monoamine oxidase in vitro (2002), J. Pharmacol. Exp. Ther., 301, 315-321.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dobutamine competitive to dopamine Homo sapiens
dopamine competitive to dobutamine Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
dobutamine
-
Homo sapiens
0.44
-
dopamine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood mononuclear cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dobutamine + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
dopamine + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens