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Literature summary for 2.1.1.6 extracted from

  • Sanft, K.; Thomas, H.
    Competitive inhibition of catechol-O-methyltransferase by tetrahydro-isochinoline alkaloids salsolidin and 1-carboxysalsolin (1989), Z. Naturforsch. C, 44, 173-176.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-Carboxysalsoline i.e. 1-carboxy-1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, competitive inhibition of 3,4-dihydroxybenzoic acid methylation Rattus norvegicus
Salsolidine i.e. 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, competitive inhibition of 3,4-dihydroxybenzoic acid methylation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-carboxy-1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
?
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.19
-
Salsolidine
-
Rattus norvegicus
0.44
-
1-Carboxysalsoline
-
Rattus norvegicus