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Literature summary for 2.1.1.37 extracted from

  • Balada, E.; Ordi-Ros, J.; Serrano-Acedo, S.; Martinez-Lostao, L.; Rosa-Leyva, M.; Vilardell-Tarres, M.
    Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus (2008), Immunology, 124, 339-347.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.37

Cloned(Commentary)

Cloned (Comment) Organism
transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, phenotype, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Homo sapiens
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information DNMT1 is constitutively expressed Homo sapiens
-
T-lymphocyte CD4+, ranscript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, an autoimmune disease with CD4+ T cells with hypomethylated DNA. It is possible that patients are reacting indirectly to an underlying DNA hypomethylation status by increasing the mRNA levels of DNA methyltransferases when the disease is definitely active, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
 Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
DNA (cytosine-5) methyltransferase
-
 Homo sapiens
DNA cytosine-5-methyltransferase 1
-
 Homo sapiens
DNA cytosine-5-methyltransferase 3A
-
 Homo sapiens
DNA cytosine-5-methyltransferase 3B
-
 Homo sapiens
Dnmt1
-
 Homo sapiens
Dnmt3a
-
 Homo sapiens
DNMT3B
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function DNMT1 is required to maintain global methylation after DNA replication has taken place Homo sapiens