Application | Comment | Organism |
---|---|---|
drug development | Dnmt inhibition is a promising strategy for the treatment of various developmental and proliferative diseases, particularly cancers | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-dC | binding modelling, overview | Homo sapiens | |
2'-deoxy-5-aza-cytidine | binding modelling, overview | Homo sapiens | |
5-azacytidine | binding modelling, overview | Homo sapiens | |
decitabine | binding modelling, overview | Homo sapiens | |
hydralazine | binding modelling, overview | Homo sapiens | |
additional information | inhibitor screening by molecular docking and molecular dynamics simulations | Homo sapiens | |
procainamide | binding modelling, overview | Homo sapiens | |
procaine | binding modelling, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Homo sapiens | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | catalytic reaction mechanism of Dnmt1, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
additional information | homology docking and molecular dynamics, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | homology model for DNMT1 based on the template structures of the available comparable protein crystal structures, molecular dynamics, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DNA methyltransferase 1 | - |
Homo sapiens |
Dnmt1 | - |
Homo sapiens |
More | the enzyme belongs to the DNA methyltransferases, Dnmt, family of enzymes that methylates DNA at the C5 position of cytosine residues | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |