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Literature summary for 2.1.1.37 extracted from

  • Satta, R.; Maloku, E.; Zhubi, A.; Pibiri, F.; Hajos, M.; Costa, E.; Guidotti, A.
    Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons (2008), Proc. Natl. Acad. Sci. USA, 105, 16356-16361.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Nicotine decreases glutamic acid decarboxylase 67 promoter methylation by DMT1 in GABAergic interneurons Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Swiss albino male mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
central nervous system
-
 Mus musculus
-
liver
-
 Mus musculus
-
neuron cortical, hippocampal, and striatal GABAergic neurons Mus musculus
-

Synonyms

Synonyms Comment Organism
DMT1
-
 Mus musculus
DNA methyltransferase 1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus nicotine decreases DNA methyltransferase 1 expression in in cortical and hippocampal but not in striatal GABAergic interneurons, while DNMT1 mRNA content in the liver fails to change after nicotine treatment, overview. Mecamylamine but not hexamethonium blocks nicotine-induced downregulation of DNMT1 expression. The downregulation proceeds via selective stimulation of nicotinic acetylcholine receptor, nAChR, overview down