Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P26358 | - |
- |
Homo sapiens | Q9UBC3 | - |
- |
Homo sapiens | Q9Y6K1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung fibroblast | neoplastically-transformed | Homo sapiens | - |
WI-38 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | control of Dnmt1, the predominant maintainance methyltransferase, is significantly suppressed in aging cells and contributes to the reduced genomic methylation of these cells. The paradoxical sporadic gene hypermethylation in aging cells appears to be related to transcriptional up-regulation of the Dnmt3b gene. Changes in transcriptional control of the Dnmts are the likely cause for the known alterations in DNA methylation in aging cells and in cells undergoing tumorigenesis | Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt1 | - |
Homo sapiens |
Dnmt3a | - |
Homo sapiens |
DNMT3B | - |
Homo sapiens |