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Literature summary for 2.1.1.37 extracted from

  • Casillas, M.A.; Lopatina, N.; Andrews, L.G.; Tollefsbol, T.O.
    Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts (2003), Mol. Cell. Biochem., 252, 33-43.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P26358
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Homo sapiens Q9UBC3
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Homo sapiens Q9Y6K1
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Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast neoplastically-transformed Homo sapiens
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WI-38 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA control of Dnmt1, the predominant maintainance methyltransferase, is significantly suppressed in aging cells and contributes to the reduced genomic methylation of these cells. The paradoxical sporadic gene hypermethylation in aging cells appears to be related to transcriptional up-regulation of the Dnmt3b gene. Changes in transcriptional control of the Dnmts are the likely cause for the known alterations in DNA methylation in aging cells and in cells undergoing tumorigenesis Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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Synonyms

Synonyms Comment Organism
Dnmt1
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Homo sapiens
Dnmt3a
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Homo sapiens
DNMT3B
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Homo sapiens