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Literature summary for 2.1.1.37 extracted from

  • Robertson, A.K.; Geiman, T.M.; Sankpal, U.T.; Hager, G.L.; Robertson, K.D.
    Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro (2004), Biochem. Biophys. Res. Commun., 322, 110-118.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
DNA
-
Homo sapiens
0.092
-
DNA
-
Homo sapiens
0.52
-
mononucleosomal DNA containing cytosine
-
Homo sapiens
1.4
-
mononucleosomal DNA containing cytosine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + DNA Homo sapiens DNMT1 interacts with hSNF2H chromatin remodeling enzyme and binds mononucleosomes with higher affinity in the presence of hSNF2H S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P26358
-
-
Homo sapiens Q9Y6K1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA DNMT1 interacts with hSNF2H chromatin remodeling enzyme and binds mononucleosomes with higher affinity in the presence of hSNF2H Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?
S-adenosyl-L-methionine + DNA free DNA or assembled into a mononucleosome. The catalytic efficiency decreases on the mononucleosome 17fold Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?
S-adenosyl-L-methionine + DNA free DNA or assembled into a mononucleosome. The catalytic efficiency decreases on the mononucleosome 8fold Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?
S-adenosyl-L-methionine + mononucleosomal DNA containing cytosine
-
Homo sapiens S-adenosyl-L-homocysteine + mononucleosomal DNA containing 5-methylcytosine
-
?