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Literature summary for 2.1.1.320 extracted from

  • Stopa, N.; Krebs, J.E.; Shechter, D.
    The PRMT5 arginine methyltransferase many roles in development, cancer and beyond (2015), Cell. Mol. Life Sci., 72, 2041-2059 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.320

Crystallization (Commentary)

Crystallization (Comment) Organism
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 Caenorhabditis elegans
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 Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine Homo sapiens PRMT5, along with PRMT3, binds to and methylate the voltage-gated sodium channel NaV1.5 2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans P46580
-
-
Homo sapiens O14744 multiple PRMT5 splice variants are found in human cells
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Xenopus laevis Q6NUA1
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-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
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 Homo sapiens
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osteosarcoma cell line
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 Homo sapiens
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U2-OS cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [protein]-L-arginine
-
 Caenorhabditis elegans 2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [protein]-L-arginine
-
 Xenopus laevis 2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine PRMT5, along with PRMT3, binds to and methylate the voltage-gated sodium channel NaV1.5 Homo sapiens 2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
Jak-binding protein 1
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 Homo sapiens
JBP1
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 Homo sapiens
PRMT5
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 Caenorhabditis elegans
PRMT5
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 Homo sapiens
PRMT5
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 Xenopus laevis

General Information

General Information Comment Organism
physiological function in stem cells, PRMT5 is only required for proliferation, and not pluripotency, through methylation of the cell cycle-regulated p57. In keratinocyte differentiation involucrin gene expression is partially controlled by PKC-delta suppression of PRMT5. In the human osteosarcoma cell line U2OS, PRMT5, Strap and p53 form a complex in response to DNA damage Homo sapiens