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Literature summary for 2.1.1.228 extracted from

  • Lahoud, G.; Goto-Ito, S.; Yoshida, K.; Ito, T.; Yokoyama, S.; Hou, Y.M.
    Differentiating analogous tRNA methyltransferases by fragments of the methyl donor (2011), RNA, 17, 1236-1246.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine
-
Escherichia coli
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine
-
Methanocaldococcus jannaschii
6-Chloropurine
-
Escherichia coli
6-Chloropurine
-
Methanocaldococcus jannaschii
adenosine
-
Escherichia coli
adenosine
-
Methanocaldococcus jannaschii
AdoButyn an S-adenosyl-L-methionine analogue Escherichia coli
AdoButyn an S-adenosyl-L-methionine analogue Methanocaldococcus jannaschii
AdoPropen an S-adenosyl-L-methionine analogue Escherichia coli
AdoPropen an S-adenosyl-L-methionine analogue Methanocaldococcus jannaschii
Inosine
-
Escherichia coli
Inosine
-
Methanocaldococcus jannaschii
methionine
-
Escherichia coli
methionine
-
Methanocaldococcus jannaschii
methylthioadenosine
-
Escherichia coli
methylthioadenosine
-
Methanocaldococcus jannaschii
additional information fragments of S-adenosyl-L-methionine, adenosine and methionine, are selectively inhibitory of TrmD, while they are poor inhibitors for Trm5 from Methanocaldococcus jannaschii Escherichia coli
additional information fragments of S-adenosyl-L-methionine, adenosine and methionine, are poor inhibitors of Trm5, while they are selectve inhibitors for TrmD from Escherichia coli Methanocaldococcus jannaschii
S-adenosyl-L-homocysteine an S-adenosyl-L-methionine analogue Escherichia coli
S-adenosyl-L-homocysteine an S-adenosyl-L-methionine analogue Methanocaldococcus jannaschii
S-methyl-L-cysteine
-
Escherichia coli
S-methyl-L-cysteine
-
Methanocaldococcus jannaschii
sinefungin an S-adenosyl-L-methionine analogue Escherichia coli
sinefungin an S-adenosyl-L-methionine analogue Methanocaldococcus jannaschii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview Escherichia coli
additional information
-
additional information S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine37 in tRNA Escherichia coli
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
?
S-adenosyl-L-methionine + guanine37 in tRNA Methanocaldococcus jannaschii
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Methanocaldococcus jannaschii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine37 in tRNA
-
Escherichia coli S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
?
S-adenosyl-L-methionine + guanine37 in tRNA
-
Methanocaldococcus jannaschii S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
?

Synonyms

Synonyms Comment Organism
TRM5
-
Methanocaldococcus jannaschii
TrmD
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Escherichia coli
55
-
assay at Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine Trm5 binding structure, detailed overview Methanocaldococcus jannaschii
S-adenosyl-L-methionine TrmD binding structure, detailed overview Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics of S-adenosyl-L-methionine analogues, overview Escherichia coli
additional information
-
additional information inhibition kinetics of S-adenosyl-L-methionine analogues, overview Methanocaldococcus jannaschii
0.00033
-
sinefungin pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.00049
-
S-adenosyl-L-homocysteine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.00062
-
sinefungin pH not specified in the publication, 37°C Escherichia coli
0.0012
-
methylthioadenosine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.00143
-
AdoPropen pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.0031
-
AdoButyn pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.0042
-
S-adenosyl-L-homocysteine pH not specified in the publication, 37°C Escherichia coli
0.0079
-
AdoButyn pH not specified in the publication, 37°C Escherichia coli
0.01
-
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine pH not specified in the publication, 37°C Escherichia coli
0.014
-
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.0259
-
AdoPropen pH not specified in the publication, 37°C Escherichia coli
0.03
-
methylthioadenosine pH not specified in the publication, 37°C Escherichia coli
0.0347
-
adenosine pH not specified in the publication, 37°C Escherichia coli
0.0642
-
adenosine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.405
-
6-Chloropurine pH not specified in the publication, 37°C Escherichia coli
0.461
-
6-Chloropurine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
0.488
-
Inosine pH not specified in the publication, 37°C Escherichia coli
6.7
-
methionine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
13.4
-
Inosine pH not specified in the publication, 55°C Methanocaldococcus jannaschii
18.2
-
methionine pH not specified in the publication, 37°C Escherichia coli
33
-
S-methyl-L-cysteine pH not specified in the publication, 37°C Escherichia coli
44
-
S-methyl-L-cysteine pH not specified in the publication, 55°C Methanocaldococcus jannaschii