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Literature summary for 2.1.1.2 extracted from
- Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy (2007), J. Appl. Physiol., 102, 2121-2127.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | GAMT is a key enzyme in the biosynthesis of creatine, deficiency leads to severe clinical symptoms, including mental retardation, muscle hypotonia, extrapyramidal movement abnormalities and epileptic seizures | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | Mus musculus | - |
S-adenosyl-L-homocysteine + creatine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| skeletal muscle | hind leg muscle | Mus musculus | - |
| thalamus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAMT | - |
Mus musculus |
| guanidinoacetate methyltransferase | - |
Mus musculus |
| guanidinoacetate N-methyltransferase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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