Literature summary for 2.1.1.2 extracted from

Takata, Y.; Fujioka, M.
Identification of a tyrosine residue in rat guanidinoacetate methyltransferase that is photolabeled with S-adenosyl-L-methionine (1992), Biochemistry, 31, 4369-4374.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	complete and irreversible inactivation by ultraviolet irradiation	Rattus norvegicus
S-adenosyl-L-homocysteine	competitive with S-adenosylmethionine	Rattus norvegicus
sinefungin	competitive with S-adenosylmethionine	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + guanidinoacetate	Rattus norvegicus	-	S-adenosyl-L-homocysteine + creatine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanidinoacetate	-	Rattus norvegicus	S-adenosyl-L-homocysteine + creatine	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0004	-	S-adenosyl-L-homocysteine	-	Rattus norvegicus
0.006	-	sinefungin	-	Rattus norvegicus

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Release 2023.1 (January 2023)