Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P36999 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine745 in 23S rRNA | methylated guanines are located in hairpin 35, in domain II of prokaryotic 23S rRNA. RrmA possesses two regions that may be responsible for specific interactions with their target nucleic acid sequences: a putative Zn-finger domain in the N-terminus and the variable domain close to the C-terminus, which indicates that the enzyme exhibits the primary structural organization distinct from other nucleic acid MTases, despite sharing the common catalytic domain | Escherichia coli | S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
23S rRNA:m1G745 methyltransferase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | mutant lacking N1-methylation of G745 exhibits increased resistance to viomycin in addition to severe defects of growth characteristics | Escherichia coli |