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Literature summary for 2.1.1.17 extracted from

  • Li, Z.; Agellon, L.B.; Vance, D.E.
    The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis (2011), Biochim. Biophys. Acta, 1811, 278-283.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibition of PEMT and/or reduction of intestinal sodium concentration may be helpful in attenuating liver damage and prolonging hepatic function in intrahepatic cholestasis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Synonyms

Synonyms Comment Organism
PEMT
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Mus musculus
phosphatidylethanolamine N-methyltransferase
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Mus musculus

General Information

General Information Comment Organism
malfunction lack of PEMT decreases liver damage in Abcb4-/- mice caused by exposure of the liver to excess bile acids. PEMT deficiency affects intestinal Na+ absorption resulting in an impaired Na+ concentration gradient along the length of the small intestine and abnormal absorption of bile acids mediated by apical sodium-dependent bile acid transporter Mus musculus