Literature summary for 2.1.1.17 extracted from

Zhao, Y.; Su, B.; Jacobs, R.L.; Kennedy, B.; Francis, G.A.; Waddington, E.; Brosnan, J.T.; Vance, J.E.; Vance, D.E.
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice (2009), Arterioscler. Thromb. Vasc. Biol., 29, 1349-1355.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine	-	Mus musculus	S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine	-	?

Synonyms

Synonyms	Comment	Organism
PEMT	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	PEMT deficiency reduces plasma homocysteine by 34% to 52% in mice deficient in both PEMT and low-density lipoprotein receptors, deletion of PEMT modestly reduces hepatic very low density lipoprotein secretion in low-density lipoprotein receptors knockout mice and alters the rate of very low density lipoprotein clearance from plasma	Mus musculus

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Release 2023.1 (January 2023)