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Literature summary for 2.1.1.17 extracted from

  • Xu, X.; Gammon, M.D.; Zeisel, S.H.; Lee, Y.L.; Wetmur, J.G.; Teitelbaum, S.L.; Bradshaw, P.T.; Neugut, A.I.; Santella, R.M.; Chen, J.
    Choline metabolism and risk of breast cancer in a population-based study (2008), FASEB J., 22, 2045-2052.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, population-based PEMT genotyping, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the PEMT G774C, i.e. rs12325817, and the CHDH G432T, i.e. rs12676, polymorphisms, causing PEMT GG genotype and the variant CC genotype, are related to breast cancer risk, while the BHMT rs3733890 polymorphism of the enzyme is not associated with breast cancer risk, genotyping, overview Homo sapiens
V175M the naturally occuring mutation is associated with diminished enzyme activity and may confer susceptibility to nonalcoholic fatty liver disease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBM1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PEMT
-
 Homo sapiens