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Literature summary for 2.1.1.17 extracted from

  • Igolnikov, A.C.; Green, R.M.
    Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet (2006), J. Hepatol., 44, 586-592.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mdr2 (+/-), Mdr2 (+/+) and wild type FVB/NJ female mice, 8-10 weeks old
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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phosphatidylethanolamine N-methyltransferase activity is significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice: 1.20 nmol/mg/min vs. 1.98 nmol/mg/min. After 7 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.31 nmol/mg/min vs. Mdr2 (+/+) = 1.96 nmol/mg/min. After 30 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.60 nmol/mg/min vs. Mdr2 (+/+) = 1.99 nmol/mg/min Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Mdr2 (+/-) and Mdr2 (+/+) mice have similar S-adenosylmethionine levels at 0 and 7 days on methionine and choline deficient diet, Mdr2 (+/-) mice have significantly higher S-adenosylmethionine levels after 30 days on methionine and choline deficient diet (40.2 vs. 6.1 nmol/g). Mus musculus additional information S-adenosylhomocysteine levels are significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice at 0 days (33.4 vs. 41.9 nmol/g) and 7 days on methionine and choline deficient diet (16.0 vs. 42.9 nmol/g). ?

Synonyms

Synonyms Comment Organism
PEMT
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Mus musculus