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Literature summary for 2.1.1.17 extracted from

  • Ridgway, N.D.; Vance, D.E.
    Phosphatidylethanolamine N-methyltransferase from rat liver (1992), Methods Enzymol., 209, 366-374.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site Rattus norvegicus
S-adenosylhomocysteine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
S-adenosylmethionine reaction with phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
0.022
-
S-adenosylmethionine reaction with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
0.08
-
phosphatidyl-N-methylethanolamine
-
Rattus norvegicus
0.45
-
phosphatidyl-N,N-dimethylethanolamine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Rattus norvegicus 5783
-
microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18300
-
1 * 18300, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.63
-
activity with phosphatidylethanolamine Rattus norvegicus
3.75
-
activity with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
8.59
-
activity with phosphatidyl-N,N-dimethyl-ethanolamine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine ordered bi-bi mechanism Rattus norvegicus 2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
Rattus norvegicus S-adenosyl-L-methionine + phosphatidylethanolamin
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine ordered bi-bi mechanism Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine transfer of three methyl groups to the amino head group of phosphatidylethanolamine Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
?

Subunits

Subunits Comment Organism
monomer 1 * 18300, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
activity increases in nearly a linear fashion between pH 6.0 and 9.5 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0049
-
S-adenosyl-L-homocysteine reaction with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
0.0067
-
S-adenosyl-L-homocysteine reaction with phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
0.0739
-
S-adenosylhomocysteine reaction with phosphatidyl-N-dimethylethanolamine Rattus norvegicus