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Literature summary for 1.8.4.11 extracted from

  • Brennan, L.A.; Lee, W.; Giblin, F.J.; David, L.L.; Kantorow, M.
    Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation (2009), Biochim. Biophys. Acta, 1790, 1665-1672.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.11

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UJ68
-
-
Mus musculus Q9D6Y7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HLEB-3 cell
-
 Homo sapiens
-
lens
-
 Mus musculus
-
lens epithelial cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 r
L-methionine (S)-sulfoxide + thioredoxin
-
 Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 r
additional information MsrA repairs methionine oxidized alpha-crystallin and restores the chaperone activity of alpha-crystallin lost upon methionine oxidation, Met-68 of alphabeta-crystallin is oxidized to protein methionine sulfoxide in the actual lens Homo sapiens ?
-
 ?
additional information MsrA repairs methionine oxidized alpha-crystallin and restores the chaperone activity of alpha-crystallin lost upon methionine oxidation, Met-68 of alphabeta-crystallin is oxidized to protein methionine sulfoxide in the actual lens Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Homo sapiens
methionine sulfoxide reductase A
-
 Mus musculus
MsrA
-
 Homo sapiens
MsrA
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Homo sapiens
thioredoxin
-
 Mus musculus