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Literature summary for 1.8.4.11 extracted from
- Essential role of methionine residues in calmodulin binding to Bordetelle pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases (2004), J. Biol. Chem., 279, 30210-30218.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of MsrA in Escherichia coli strain BL21(DE3) | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| calmodulin L-methionine-(S)-sulfoxide + thioredoxin | Rattus norvegicus | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | calmodulin L-methionine + thioredoxin disulfide | - |
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Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant MsrA from Escherichia coli strain BL21(DE3) | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| calmodulin L-methionine-(S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | Rattus norvegicus | calmodulin L-methionine + thioredoxin disulfide | - |
? | |
| calmodulin L-methionine-(S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, recombinant human calmodulin, recombinant rat enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview | Rattus norvegicus | calmodulin L-methionine + thioredoxin disulfide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrA | - |
Rattus norvegicus |
| peptide methionine sulfoxide reductase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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