Cloned (Comment) | Organism |
---|---|
gene msrA, DNA and amino acid sequence determination and analysis, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates | Mycobacterium tuberculosis |
gene msrA, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates | ? | - |
? | |
additional information | Mycobacterium tuberculosis | MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Escherichia coli | stereospecific reduction | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Mycobacterium tuberculosis | stereospecific reduction | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene msrA, strain MC1061 | - |
Mycobacterium tuberculosis | - |
gene msrA, strains CB3.3, 1254, and H37Rv | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity in wild-type and recombinant strain | Escherichia coli |
additional information | - |
activity in wild-type strain and recombinant Escherichia coli strain | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates | Escherichia coli | ? | - |
? | |
additional information | MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates | Mycobacterium tuberculosis | ? | - |
? | |
N-acetyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Escherichia coli | N-acetyl-L-methionine + DTT disulfide + H2O | - |
? | |
N-acetyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Mycobacterium tuberculosis | N-acetyl-L-methionine + DTT disulfide + H2O | - |
? | |
N-acetyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Escherichia coli | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
N-acetyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Mycobacterium tuberculosis | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Escherichia coli | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Mycobacterium tuberculosis | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 21000-27000, about, recombinant MsrA, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Escherichia coli |
MsrA | - |
Mycobacterium tuberculosis |
peptide methionine sulfoxide reductase | - |
Escherichia coli |
peptide methionine sulfoxide reductase | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Escherichia coli | |
dithiothreitol | - |
Mycobacterium tuberculosis | |
thioredoxin | - |
Escherichia coli | |
thioredoxin | - |
Mycobacterium tuberculosis |