Cloned (Comment) | Organism |
---|---|
gene msrA, expression in Escherichia coli as GST-fusion protein | Streptococcus pneumoniae |
gene pilB, expression in Escherichia coli | Neisseria gonorrhoeae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutants defective in the pilA-pilB locus show affected ligand binding and impaired hemagglutination, the mutants' ability to bind eukaryotic receptors is altered, overview | Escherichia coli |
additional information | mutation of msrA affects the adherence of pneumococci to epithelial cells, overview | Streptococcus pneumoniae |
additional information | mutation of pilB affects the adherence of gonococci to epithelial cells, overview | Neisseria gonorrhoeae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | ? | - |
? | |
additional information | Neisseria gonorrhoeae | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | ? | - |
? | |
additional information | Streptococcus pneumoniae | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | ? | - |
? | |
additional information | Neisseria gonorrhoeae MS11A | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | ? | - |
? | |
additional information | Streptococcus pneumoniae R6x | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Escherichia coli | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Neisseria gonorrhoeae | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Streptococcus pneumoniae | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Neisseria gonorrhoeae MS11A | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Streptococcus pneumoniae R6x | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
strains MC1061 and SK8779 | - |
Neisseria gonorrhoeae | - |
derivatives, bifunctional enzyme MsrA/B, gene pilB | - |
Neisseria gonorrhoeae MS11A | - |
derivatives, bifunctional enzyme MsrA/B, gene pilB | - |
Streptococcus pneumoniae | - |
gene msrA | - |
Streptococcus pneumoniae R6x | - |
gene msrA | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | Escherichia coli | ? | - |
? | |
additional information | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | Neisseria gonorrhoeae | ? | - |
? | |
additional information | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | Streptococcus pneumoniae | ? | - |
? | |
additional information | the bifunctional enzyme catalyzes both reactions of MsrB or PilB, EC 1.8.4.12, and of MsrA or PilA, EC 1.8.4.11, the catalytic sites for the two different activities are localized separately on the enzyme molecule, overview | Neisseria gonorrhoeae | ? | - |
? | |
additional information | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | Neisseria gonorrhoeae MS11A | ? | - |
? | |
additional information | the bifunctional enzyme catalyzes both reactions of MsrB or PilB, EC 1.8.4.12, and of MsrA or PilA, EC 1.8.4.11, the catalytic sites for the two different activities are localized separately on the enzyme molecule, overview | Neisseria gonorrhoeae MS11A | ? | - |
? | |
additional information | the enzyme contributes to the maintenance of adhesins in the pathogen, overview | Streptococcus pneumoniae R6x | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Escherichia coli | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Neisseria gonorrhoeae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Streptococcus pneumoniae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Escherichia coli | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Neisseria gonorrhoeae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Streptococcus pneumoniae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Neisseria gonorrhoeae MS11A | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Neisseria gonorrhoeae MS11A | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Streptococcus pneumoniae R6x | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Streptococcus pneumoniae R6x | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptide methionine sulfoxide reductase | - |
Escherichia coli |
peptide methionine sulfoxide reductase | - |
Neisseria gonorrhoeae |
peptide methionine sulfoxide reductase | - |
Streptococcus pneumoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Escherichia coli | |
thioredoxin | - |
Neisseria gonorrhoeae | |
thioredoxin | - |
Streptococcus pneumoniae |