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Literature summary for 1.8.4.11 extracted from

  • Wizemann, T.M.; Moskovitz, J.; Pearce, B.J.; Cundell, D.; Arvidson, C.G.; So, M.; Weissbach, H.; Brot, N.; Masure, H.R.
    Peptide methionine-sulfoxide reductase contributes to the maintenance of adhesions in three major pathogens (1996), Proc. Natl. Acad. Sci. USA, 93, 7985-7990.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene msrA, expression in Escherichia coli as GST-fusion protein Streptococcus pneumoniae
gene pilB, expression in Escherichia coli Neisseria gonorrhoeae

Protein Variants

Protein Variants Comment Organism
additional information mutants defective in the pilA-pilB locus show affected ligand binding and impaired hemagglutination, the mutants' ability to bind eukaryotic receptors is altered, overview Escherichia coli
additional information mutation of msrA affects the adherence of pneumococci to epithelial cells, overview Streptococcus pneumoniae
additional information mutation of pilB affects the adherence of gonococci to epithelial cells, overview Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli the enzyme contributes to the maintenance of adhesins in the pathogen, overview ?
-
?
additional information Neisseria gonorrhoeae the enzyme contributes to the maintenance of adhesins in the pathogen, overview ?
-
?
additional information Streptococcus pneumoniae the enzyme contributes to the maintenance of adhesins in the pathogen, overview ?
-
?
additional information Neisseria gonorrhoeae MS11A the enzyme contributes to the maintenance of adhesins in the pathogen, overview ?
-
?
additional information Streptococcus pneumoniae R6x the enzyme contributes to the maintenance of adhesins in the pathogen, overview ?
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli
-
peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin Neisseria gonorrhoeae
-
peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin Streptococcus pneumoniae
-
peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin Neisseria gonorrhoeae MS11A
-
peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin Streptococcus pneumoniae R6x
-
peptide-L-methionine + thioredoxin disulfide + H2O
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
strains MC1061 and SK8779
-
Neisseria gonorrhoeae
-
derivatives, bifunctional enzyme MsrA/B, gene pilB
-
Neisseria gonorrhoeae MS11A
-
derivatives, bifunctional enzyme MsrA/B, gene pilB
-
Streptococcus pneumoniae
-
gene msrA
-
Streptococcus pneumoniae R6x
-
gene msrA
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme contributes to the maintenance of adhesins in the pathogen, overview Escherichia coli ?
-
?
additional information the enzyme contributes to the maintenance of adhesins in the pathogen, overview Neisseria gonorrhoeae ?
-
?
additional information the enzyme contributes to the maintenance of adhesins in the pathogen, overview Streptococcus pneumoniae ?
-
?
additional information the bifunctional enzyme catalyzes both reactions of MsrB or PilB, EC 1.8.4.12, and of MsrA or PilA, EC 1.8.4.11, the catalytic sites for the two different activities are localized separately on the enzyme molecule, overview Neisseria gonorrhoeae ?
-
?
additional information the enzyme contributes to the maintenance of adhesins in the pathogen, overview Neisseria gonorrhoeae MS11A ?
-
?
additional information the bifunctional enzyme catalyzes both reactions of MsrB or PilB, EC 1.8.4.12, and of MsrA or PilA, EC 1.8.4.11, the catalytic sites for the two different activities are localized separately on the enzyme molecule, overview Neisseria gonorrhoeae MS11A ?
-
?
additional information the enzyme contributes to the maintenance of adhesins in the pathogen, overview Streptococcus pneumoniae R6x ?
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
Neisseria gonorrhoeae peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
Streptococcus pneumoniae peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Neisseria gonorrhoeae peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Streptococcus pneumoniae peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
Neisseria gonorrhoeae MS11A peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Neisseria gonorrhoeae MS11A peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin
-
Streptococcus pneumoniae R6x peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Streptococcus pneumoniae R6x peptide-L-methionine + thioredoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
peptide methionine sulfoxide reductase
-
Escherichia coli
peptide methionine sulfoxide reductase
-
Neisseria gonorrhoeae
peptide methionine sulfoxide reductase
-
Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Escherichia coli
thioredoxin
-
Neisseria gonorrhoeae
thioredoxin
-
Streptococcus pneumoniae