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Literature summary for 1.6.2.4 extracted from

  • Lee, H.; Park, H.G.; Lim, Y.R.; Lee, I.S.; Kim, B.J.; Seong, C.H.; Chun, Y.J.; Kim, D.
    Functional expression and characterization of recombinant NADPH-P450 reductase from Malassezia globosa (2012), J. Microbiol. Biotechnol., 22, 141-146.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expression in Escherichia coli strain DH5alpha Malassezia globosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetics of P450 enzyme reactions supported by Malassezia globosa NPR, overview Malassezia globosa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Malassezia globosa 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80740
-
x * 80740, SDS-PAGE Malassezia globosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + cytochrome c Malassezia globosa
-
NADP+ + reduced cytochrome c
-
?

Organism

Organism UniProt Comment Textmining
Malassezia globosa A8PYK0
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Escherichia coli strain DH5alpha Malassezia globosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NADPH-dependent reducing activity for cytochrome c or nitroblue tetrazolium Malassezia globosa ?
-
?
NADPH + H+ + cytochrome c
-
Malassezia globosa NADP+ + reduced cytochrome c
-
?

Subunits

Subunits Comment Organism
? x * 80740, SDS-PAGE Malassezia globosa

Synonyms

Synonyms Comment Organism
NADPH-P450 reductase
-
Malassezia globosa
NPR
-
Malassezia globosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Malassezia globosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Malassezia globosa

Cofactor

Cofactor Comment Organism Structure
flavin
-
Malassezia globosa
NADPH
-
Malassezia globosa

General Information

General Information Comment Organism
metabolism human P450 1A2 and 2A6 are able to successfully catalyze the O-deethylation of 7-ethoxyresorufin and the 7-hydroxylation of coumarin, respectively, with the support of the purified enzyme NPR. Purified NPR is an orthologous reductase protein that supports cytochrome P450 enzymes in Malassezia globosa Malassezia globosa