Protein Variants | Comment | Organism |
---|---|---|
additional information | comparison of enzyme gene expression in enterocytes isolated from the small intestine of intestinal epithelium-specific Por knock-out mice, i.e. IE-Cpr-null mice, and that observed in wild-type littermates, overview. Cholesterol biosynthetic activity is greatly reduced in the enterocytes of the IE-Cpr-null mice, as evidenced by the accumulation of the lanosterol metabolite, 24-dihydrolanosterol. Levels of the cholesterol precursor farnesyl diphosphate and its derivative geranylgeranyl pyrophosphate are also increased in the enterocytes of the IE-Cpr-null mice. Expression of STAT1 (signal transducer and activator of transcription 1), a downstream target of geranylgeranyl pyrophosphate signaling, is enhanced | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
enterocyte | - |
Mus musculus | - |
small intestine | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P450 reductase | - |
Mus musculus |
NADPH-cytochrome P450 reductase | - |
Mus musculus |
POR | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | NADPH-cytochrome P450 reductase is essential for the functioning of microsomal cytochrome P450 monooxygenases and heme oxygenases. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine in expression of major histocompatibility complex class II genes | Mus musculus |