Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.2.4 extracted from

  • Christensen, H.; Hestad, A.L.; Molden, E.; Mathiesen, L.
    CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity (2011), Xenobiotica, 41, 1-5.
    View publication on PubMed

Application

Application Comment Organism
additional information the CPR activity in different recombinant enzyme preparations is crucial for in vitro CYP3A5-mediated clearance of midazolam. The level of CPR affects both the affinity/binding of midazolam to the CYP enzyme and the velocity of the metabolic reaction Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in microsome from baculovirus-infected insect cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
CPR
-
Homo sapiens
NADPH-cytochrome P450 reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens