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Literature summary for 1.6.2.4 extracted from

  • Liu, K.H.; Kim, M.J.; Jeon, B.H.; Shon, J.H.; Cha, I.J.; Cho, K.H.; Lee, S.S.; Shin, J.G.
    Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba (2006), J. Clin. Pharm. Ther., 31, 83-91.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the herbal medicines Epimedii herba, Glycyrrhizae radix and Leonuri herba inhibit one or more NADPH-CYP reductase. Epimedii herba extract is the most potent inhibitor, IC50: 0.1859 mg/ml Homo sapiens
quercetin IC50: 0.00088 mg/ml Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADPH
-
Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
?

Synonyms

Synonyms Comment Organism
NADPH-CYP reductase
-
Homo sapiens